Ketamine Infusions for Depression & Pain • Free Consultations for New Patients 850-906-5049



New Horizon Clinics offers ketamine treatment across the state of Florida, with practicing clinicians located at our offices in Tallahassee, Bainbridge, Cairo, Thomasville, and Valdosta. Owned and operated by some of Florida’s leading physicians, our team is highly experienced in ketamine therapy administration. We rely on proven protocols, personalizing each treatment plan to the needs of the patient, in order to maximize results.

Ketamine was approved by the FDA in 1970 as a general anesthetic.  However, research done over the past 10-15 years has shown the potential for Ketamine to have a positive effect on a wide array of mood and certain pain disorders. It has become a widely-researched and innovative off-label treatment to help individuals who have been resistant to traditional treatment in the past. The World Health Organization (WHO) has also listed ketamine as an essential medication due to its therapeutic properties and its impressive safety profile.

Ketamine uniquely works in the brain to create new neural pathways. Along with reversing damage, ketamine has also been seen to have an anti-inflammatory effect which has created a powerful, effective treatment for a variety of chronic mental illness and pain conditions.

How Does Ketamine Work?

The mechanism of action of ketamine is not clearly defined. It has, however,  been determined that ketamine’s effect on depressive and PTSD symptoms are unique, and therefore may provide relief when traditional treatments have failed.

A likely target for ketamine are NMDA receptors specifically in the brain. When ketamine binds to these receptors, an increase in the amount of a neurotransmitter called glutamate in the spaces between neurons is seen. Glutamate then stimulates another receptor, the AMPA receptor. Together, the initial blockade of NMDA receptors and subsequent stimulation of AMPA receptors lead to the release of other neurotransmitters that help nerve cells communicate with each other along brand new pathways. This is called synaptogenesis.  This process is thought to affect mood, thought patterns, and cognition.*

Ketamine likely influences depression in other ways as well.  It might reduce signals involved in inflammation, which has also a contributing factor to mood disorders.  Facilitation of communication within specific areas in the brain are also possible through the synaptogenic process. As with many therapies,  ketamine likely works in many ways once. Many of these mechanisms are being studied.


When administered intravenously at low doses, ketamine has incredible antidepressant effects. At New Horizon Clinics, we find that an initial protocol of 4-6 ketamine infusions administered over the course of two weeks is effective for about 70% of patients—even those who have resisted other depression treatments in the past. Most patients will know whether ketamine will work for them within 1-2 infusions. Each infusion lasts about 40-minutes, and side effects are generally mild: nausea and mild, non-threatening hallucinations are most common.


Learn how ketamine infusion therapy can help you regain control of your life. Call our offices today to schedule a free consultation to see if ketamine treatment is the right solution for you.

Ketamine for PTSD

Ketamine for Anxiety

Ketamine for Fibromyalgia

Why to Consider Ketamine Therapy

Treatment is Fast and Effective

Ketamine therapy takes effect quickly and may provide relief within hours of your first treatment. 

Ketamine has a long history of Success

For over 50 years, Ketamine has been used to treat a variety of ailments in a supervised setting. 

Ketamine is Safe

With minimal side effects, and tremendous relief, Ketamine is a safe treatment option when monitored appropriately.

What Should I Expect at my Ketamine Therapy?

At New Horizon Infusion Clinics, we strive to achieve the best outcome possible for our patients seeking ketamine infusion therapy.  Ketamine is not appropriate for every patient,  and our process is designed to ensure ketamine is the right treatment option for your condition. Here is an article that discusses everything you can expect when doing ketamine infusion treatments.

The Science Behind Ketamine Therapy and Pain

In the treatment of chronic pain, it is crucial because at lower doses it acts as an NDMA receptor agonist, effectively closing the channel for ion transport and blocking transmission of the pain signal. This allows the neuron to repair itself and resume functioning at a higher, more typical level of transmission. One or multiple infusions of ketamine can significantly reduce pain, and sometimes even eliminate it entirely for an extended period of time.

The dorsal horn of the spinal cord contains the NDMA receptor, which plays a key role in the conduction of pain signals from the periphery to the central nervous system. As a result of these extraneous stimuli, glutamate is secreted and binds to its receptor. Through this binding, the NDMA receptor channel opens, allowing ions to flood in and stimulating neurochemical events that underlie the experience of pain in the brain. The brain becomes sensitized after repeated exposure. The NDMA receptor is then blocked by ketamine, which effectively terminates the pain signal from the body to the brain. Long-term ketamine blockade causes a reset in the brain, so that the body no longer registers the periphery’s stimuli as painful

The Impact of Ketamine on the Brain and Mental Health

We know that ketamine, Esketamine, and ketamine-like drugs can alleviate some of the symptoms of mental disorders like anxiety and depression, but many scientists who question its advocacy also encourage more rigorous testing because of its potential benefits.

People with PTSD may benefit from ketamine infusion therapy because the amygdala, the brain region responsible for processing fear and emotion, is overactive in this condition. U.S. veterans with post-traumatic stress disorder can now use this medication, thanks to its approval by the Department of Veterans Affairs. Studies involving ketamine have brought attention to the importance of that region of the brain in addressing the symptoms of anxiety and depression.

The amygdala: what else do we know about it? It shares a neighborhood with the hippocampus, another important brain region. Many of the affective disorders that ketamine may be able to treat have their origins in the subconscious, where decisions are made, punishments and rewards are doled out, emotional responses are regulated, and memories are stored.

It has been shown that ketamine can be helpful for people experiencing depression, anxiety, post-traumatic stress disorder, and migraines.



What is Ketamine?

Ketamine was FDA approved for use as a dissociative anesthetic and analgesic medication in the 1970s. In the 1990s, researchers discovered that ketamine had impressive antidepressant effects. When used as an antidepressant, ketamine works on the brain’s glutamate system to repair damaged neural connections and encourage the brain to create new, healthy neural pathways.


What Conditions can be treated with Ketamine?

Ketamine is effective for the treatment of such psychiatric conditions as severe depression, anxiety, post-traumatic stress disorder (PTSD), bipolar disorder, and postpartum depression. Ketamine is also effective for certain pain conditions, such as chronic regional pain syndrome (CRPS), fibromyalgia, migraine headaches, phantom limb pain, diabetic nerve pain, rheumatoid arthritis and more.


Is Ketamine Addictive?

Ketamine is not a physically addictive substance. When abused recreationally, ketamine can result in psychological addiction. For the treatment of depression and certain pain conditions, ketamine is administered in a clinical setting by a medical professional—and at much lower doses than what would be used in a recreational setting. Furthermore, patients are not provided with a take-home prescription for ketamine, which dramatically reduces the chance of abuse or misuse.


Is Ketamine Therapy Legal in Florida?

Yes, ketamine therapy in Florida—and across the United States—is completely legal.


Find a Ketamine Doctor in Florida

New Horizon Clinics offers ketamine therapy in Florida. Our ketamine clinics are located in ​Tallahassee, Bainbridge, Cairo, Thomasville, and Valdosta and we are accepting new patients. If you are ready to explore a new avenue of hope for your psychiatric or pain condition, contact us today for a free consultation.


How Does New Horizon’s Ketamine Treatment work?

New Horizon seeks to provide our patients with the best possible outcome from ketamine therapy.  We recognize the importance of ensuring a candidate is right for treatment, as well as the importance of follow-up to monitor outcomes.
For this reason, we have a multiple tools we offer our patients.
  1. Fill out a contact form online.  Once this is done, either our therapist or medical personnel will reach out to evaluate you to see if ketamine is right for you.
  2. If approved, we will schedule you for a Ketamine infusion appointment
  3. Download the OSMIND app.  We will use this Ketamine specific service to evaluate how your treatment is working and to complete all required paperwork.
  4. Begin your treatments. Our therapist will follow up with you after each treatment.

What does Ketamine feel like?

Every patient will experience ketamine infusions differently. Many patients feel pleasantly relaxed during their infusions. Some experience mild, non-threatening hallucinations, while other feel drowsy. Generally, the side effects of ketamine wear off within 2-hours of an infusion. We don’t recommend that patients drive or operate heavy machinery on the day of their infusion.


Does Ketamine have any Side Effects?

The most common side effects of ketamine include: hallucinations, nausea and vomiting, increased saliva production, dizziness, blurred vision, increased heart rate and blood pressure during the infusion, out-of-body experience during the infusion, and changes in motor skills. Uncommon side effects include: rash; double vision; pain and redness in the injection site -Increased pressure in the eye; and jerky arm movements resembling a seizure. For a complete list of side effects, please ask a member of our clinical team.

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New Horizon Ketamine Infusion Clinic

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New Horizon Infusion Clinics
2633-B Mahan Drive
Tallahassee, FL 32308